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Weight Regain Observed in Patients After Ending Obesity Drug Treatment

INTERNATIONAL (MULTIPLE COUNTRIES), JUL 22 – A meta-analysis of 11 trials with 1,574 patients found weight regain begins eight weeks after stopping anti-obesity drugs and continues for 20 weeks before leveling off.

  • On Tuesday, the meta-analysis in BMC Medicine assessed data from 11 clinical trials involving nearly 2,500 participants, revealing that patients broadly regain weight after stopping anti-obesity medications.
  • Reviewing prior findings, researchers led by Xiaoling Cai examined gaps in long-term AOM effects, addressing the lack of systematic evaluation, to inform personalized obesity management strategies.
  • The analysis showed weight regain began eight weeks after AOM discontinuation, continued for about 20 weeks, the study found, published on Tuesday.
  • The review recommends more studies with longer follow-up periods to better understand weight change after stopping anti-obesity medications, informing personalized prevention strategies.
  • Considering medication differences, the study suggests these patterns could guide personalized long-term obesity management strategies, with future research focusing on drug and lifestyle factors.
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Medical Xpress broke the news in on Monday, July 21, 2025.
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