AI model simulates 500 million years of evolution to generate a new fluorescent protein

AI model simulates 500 million years of evolution to generate a new fluorescent protein

A team of AI researchers, biologists and evolutionary specialists at EvolutionaryScale and the Arc Institute, both in the U.S., has designed and built an AI model capable of generating the code to synthesize novel proteins. In their paper published in the journal Science, the group describes the factors that went into developing their new AI model, which they call ESM3, and how they used it to synthesize a previously unknown bright, fluorescent …

Fast-Forwarding Evolution: AI Mimics 500 Million Years of Biology

Researchers used AI model ESM3 to simulate 500 million years of evolution and create a novel fluorescent protein, revolutionizing protein engineering. Using a multimodal generative language model called ESM3, Thomas Hayes and colleagues designed and synthesized a novel bright fluorescent protein with a genetic sequence vastly different from any known fluorescent proteins. The researchers [...]

AI simulates 500 million years of evolution to discover artificial fluorescent protein

Scientists are pondering whether evolution could have unfolded differently. For instance, was it inevitable that humans would emerge, or are we the product of a series of natural accidents that might not have happened, and would have led to an entirely different world? While there is no definitive answer, artificial intelligence (AI) is now capable of conducting evolutionary experiments. One such study, published last week in the journal Science…