Study Identifies Potential New Treatment Targets for the Most Common Type of Bowel Cancer
The team found tumor vulnerabilities and drug combinations in models, including approved drugs, and said the approach could speed clinical testing.
8 Articles
8 Articles
Study identifies potential new treatment targets for the most common type of bowel cancer
Research published today identifies potential new ways to treat the most common type of colorectal cancer in Ireland. The study, conducted by an international research team led by RCSI University of Medicine and Health Sciences and The Institute of Cancer Research, London, provides a roadmap for repurposing existing drugs and developing new ones to create more effective, personalized treatments for thousands of patients who currently have limited options.
Scientists find how to treat hard-to-treat bowel cancer
Scientists have uncovered possible weaknesses in a common form of bowel cancer that often responds poorly to newer treatments. The discovery could guide future combinations of existing drugs, although the promising results are still preclinical. The research focused on microsatellite-stable colorectal cancer, known as MSS disease. This type makes up most colorectal cancers and has […]
AI map of bowel tumours reveals drug vulnerabilities in hardest-to-treat
An international team led by RCSI and The Institute of Cancer Research, London, used an AI tool called iPhenMap to analyse 2,000 colorectal tumour samples, uncovering previously unrecognised vulnerabilities in microsatellite-stable bowel cancer and identifying drug combinations, including the approved targeted drug trametinib, that showed promise in laboratory models.
Multiomic Study of MSS CRC Identifies Vulnerabilities Pointing to Therapeutic Possibilities
Researchers analyzed mulitomic and clinical data from 2000 colorectal cancer samples and used an AI tool, iPhenMap, to help identify cancer cell vulnerabilities and drug combinations that could be used to treat MSS CRC. The post Multiomic Study of MSS CRC Identifies Vulnerabilities Pointing to Therapeutic Possibilities appeared first on GEN - Genetic Engineering and Biotechnology News.
ICR and RCSI Researchers Identify Potential Drug Combinations for Common Bowel Cancer Subtype
International study uses iPhenMap AI analysis of 2,000 tumour samples to uncover preclinical treatment opportunities in microsatellite stable colorectal cancer. IN BRIEFKEY TAKEAWAYSFAQs An international research team led by The Institute of Cancer Research, London and RCSI University of Medicine … Read the full press release →
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