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Deep Learning Algorithm Uses Mammograms and Age for Heart Disease Prediction

Researchers developed a deep learning model analyzing mammograms from nearly 50,000 women to predict cardiovascular events, matching traditional risk calculators in accuracy, study shows.

  • Researchers at The George Institute for Global Health, with the University of New South Wales and the University of Sydney, developed a machine learning model analyzing routine mammograms to predict women's cardiovascular risk, published in the journal Heart.
  • Because cardiovascular disease remains the leading cause of death worldwide, researchers aimed to repurpose routine mammography to better detect risk in women often underdiagnosed and undertreated for CVD.
  • The team trained the algorithm on routine mammograms from 49,196 women aged 35–94 with a mean age around 60; nearly 3,400 events occurred during follow-up and it performed comparably with AHA and PREVENT calculator.
  • The approach could provide a cost-effective 'two-for-one' screening option, with researchers saying it could soon be scaled globally but requires further validation in diverse populations.
  • Transitioning the model into routine clinical use could revolutionize preventive cardiology by improving early risk stratification in women undergoing routine mammography, as the study linked imaging data to hospital and mortality records for precise correlation with major adverse cardiac events.
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Can Mammograms Assess Women's Heart Health?

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Inside Precision Medicine broke the news in on Tuesday, September 16, 2025.
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