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Christina Applegate reveals she was misdiagnosed with MS

Applegate said the correction leaves her with ongoing symptoms and unanswered questions, while doctors investigate what caused the original diagnosis.

  • On Tuesday, actress Christina Applegate revealed on her MeSsy podcast that she was misdiagnosed with multiple sclerosis in 2021. Despite the revoked diagnosis, her debilitating symptoms persist, leaving her feeling "back at square one."
  • Advanced brain MRI technology recently led doctors to determine Applegate does not have the condition. Dr. Marwa Kaisey, associate professor at Cedars-Sinai Medical Center department of neurology, notes that because no single test exists for MS, misdiagnosis is "fairly common," affecting nearly 20% of patients.
  • Following her 2021 diagnosis, Applegate retired from acting and became a prominent advocate for the MS community alongside co-host Jamie-Lynn Sigler. She tearfully acknowledged feeling confused, as she previously viewed the diagnosis as an explanation for her daily physical struggles.
  • Medical teams plan to begin a new investigation next week to identify the cause of her ongoing symptoms. Applegate described the sudden change in medical understanding as a "mindf**k," noting that her health challenges have not improved despite the revised diagnosis.
  • Daily life remains difficult for Applegate, who continues to rely on mobility aids while seeking answers. Her return to the podcast after a seven-month hiatus highlights the complex emotional process of navigating a chronic health journey without a definitive diagnosis.
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The 54-year-old actress discovered after five years of struggle that she does not suffer from neurological condition, although she continues to experience severe physical deterioration

·Los Angeles, United States
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A well-known actress in the series "The Bundy Family Talked about the news "disturbing" and "very confusing" that the diagnosis she received five years ago, that she suffers from multiple sclerosis, was a mistake. After she became a strong supporter of the awareness campaign about multiple sclerosis – a disease ...

·Romania
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TMZ broke the news in Burbank, United States on Tuesday, October 20, 2026.
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