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Brock Purdy's 5-Td Night Powers 49ers Past Colts

Brock Purdy threw five touchdown passes to lead San Francisco’s fifth straight win, with Dee Winters scoring on a 74-yard interception return in a 48-27 victory.

  • On Monday night, the San Francisco 49ers defeated the Indianapolis Colts 48-27 as Brock Purdy threw a career-high five touchdown passes and Dee Winters returned Philip Rivers' final pass for a touchdown.
  • Purdy's red-zone command contrasted with Indianapolis Colts losing multiple offensive-line starters early, including Braden Smith, Bernhard Raimann, and Tanor Bortolini.
  • Statistically, Brock Purdy completed 25 of 34 passes with one interception, Christian McCaffrey, 49ers running back, rushed 21 times and scored twice, and George Kittle, 49ers tight end, had seven receptions and one touchdown.
  • Having clinched a playoff berth Sunday, the San Francisco 49ers now control their destiny and can secure top NFC seeding by winning their final two games.
  • Colts' slump means they have lost five straight, leaving playoff hopes nearly gone and requiring a win-out plus help scenario.
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  • 60% of the sources are Center
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NBC Bay Area broke the news in San Francisco, United States on Monday, December 22, 2025.
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