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49ers injury report: George Kittle, Nick Bosa, and Christian McCaffrey cleared to play vs. Rams
George Kittle, Nick Bosa and Christian McCaffrey are expected to play after San Francisco cleared its final injury report with one player ruled out.
The San Francisco 49ers open their 2026 season Friday against the Los Angeles Rams at Melbourne Cricket Ground, with stars Nick Bosa, George Kittle, and Christian McCaffrey all confirmed to play after managing injury recoveries.
Both Bosa and Kittle return from season-altering injuries: Bosa from a torn ACL sustained in Week 3 of the 2025 season against the Arizona Cardinals, and Kittle from an Achilles tear suffered during January's Wild Card playoff victory.
Head coach Kyle Shanahan announced the 49ers lost defensive tackle Alfred Collins for the season after a torn patellar tendon injury during Monday practice, making him the only player ruled out for the opener.
Los Angeles will be without defensive tackle Aaron Donald, who did not travel to Australia, though blockbuster offseason acquisition Myles Garrett is expected to make his team debut against San Francisco.
This historic matchup marks the first regular-season NFL game ever played in Australia, streaming live on Netflix with coverage starting at 6:30 PM ET on Friday, September 11, 2026.
OverDrive discuss the 49ers–Rams Melbourne opener, weighing injuries to Nick Bosa and George Kittle, Christian McCaffrey’s role, and travel factors in their game picks