US EditionMale Age over 45 Linked to Higher Miscarriage Risk in IVF with Donor Eggs
- On June 29, 2025, researchers shared findings from an international study indicating that men older than 45 experience higher miscarriage rates and reduced chances of live birth in IVF treatments using donor eggs.
- The research reviewed data from 1,712 initial IVF cycles using donor eggs conducted between 2019 and 2023 in Italy and Spain, controlling for maternal factors to specifically assess the influence of paternal age.
- Men older than 45 experienced miscarriage rates of 23.8%, higher than the 16.3% observed in younger men, and their live birth rates declined to 35.1% compared to 41%, despite the exclusive use of eggs from young healthy donors.
- Dr. Guglielmo explained that paternal age affects sperm integrity through increased DNA mutations, sperm aneuploidy, and epigenetic changes, impairing embryo development and raising miscarriage risk.
- These results emphasize that fertility specialists should consider paternal age during counseling, recommending early consultations to enhance IVF success rates and guide appropriate prenatal screening decisions.
62 Articles
62 Articles
Male age over 45 linked to higher miscarriage risk in IVF with donor eggs
A new international study presented today at the 41st Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE) reveals that IVF cycles involving male partners over the age of 45 carry significantly increased miscarriage risks and lower live birth rates – even when young donor eggs are used.
Rutland Herald
ESHRE 41st Annual Meeting: Older paternal age linked to higher miscarriage risk and lower live birth rates in donor egg IVF cycles
A new international study presented today at the 41st Annual Meeting of the European Society of Human Reproduction and Embryology (ESHRE) reveals that IVF cycles involving male partners over the age of 45 carry significantly increased miscarriage risks and lower…
Longview News-Journal
CNHI News41st Eshre Annual Meeting: Advanced Paternal Age Is Associated with an Increased Risk of Miscarriage
41st ESHRE Annual Meeting: Advanced paternal age is associated with an increased risk of miscarriage and lower live birth rates in donor egg IVF cycles
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