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Zika vaccine tweak triggered an unexpected immune defense
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Zika vaccine tweak triggered an unexpected immune defense
A modified Zika vaccine protected mice almost entirely through virus-killing CD8 T cells when its antibodies failed to neutralize mature virus effectively. The T-cell protection worked shortly after vaccination but disappeared by 12 weeks, while a vaccine that activated both antibodies and T cells remained protective. The experiments show that altering a viral protein to reduce antibody-dependent enhancement can unintentionally disrupt vaccine-p…
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