You Likely Have Genes that Affect How Well Your Medications Work – Testing for Them Could Improve Treatment
Researchers found 99.5% of participants carried variants that can change prescribing, and about 24% had already taken a affected drug.
- Analyzing nearly 100,000 genomes, University of Pittsburgh researcher Philip Empey and his team found nearly all people carry drug-response gene variants using data from the National Institutes of Health All of Us Research Program.
- Clinicians often rely on trial-and-error prescribing, a practice historically limited by insufficient diversity in genetic research data that has prevented pharmacogenomics from becoming routine medical practice.
- Around 99.5% of participants carried variants where Food and Drug Administration guidelines suggest adjusting medication, while 1 in 4 already take drugs affected by their specific genetics.
- Researchers identified 17,704 previously unreported variants, providing new data to enhance the precision medicine databases that clinicians and researchers use routinely to guide patient care and prescribing decisions.
- Beyond DNA variation, age, kidney and liver function, and other medications also influence how individuals process drugs, meaning genetic testing remains not yet routine despite the prevalence of variants identified by the NIH study.
22 Articles
22 Articles
A study found that nearly every participant carried genetic variants linked to how common medications work—but that does not mean their prescriptions are unsafe
A study of nearly 100,000 All of Us participants found widespread genetic variants linked to medication response, though researchers stressed the findings show potential exposure—not proof of side effects or treatment failure.
The Conversation
You likely have genes that affect how well your medications work – testing for them could improve treatment
Pharmacogenomics studies how genetics interacts with drugs. Utku Yilmazturk/iStock via Getty ImagesAll people carry differences in their DNA that could affect how they respond to medication, according to my team’s newly published research. Moreover, 1 in 4 already take a medication their body processes differently because of their genetics. Clinicians often take a trial and error approach to prescriptions. Two people take the same medicine at th…
Could your genes affect your medications? New study highlights high probability
Everyone in a diverse, nearly 100,000-person sample carried at least one genetic variant that affects how their body processes medications, and a quarter of those people had been prescribed a medication that is known to be impacted by the variant they carried, a new University of Pittsburgh–led analysis reveals in Science Translational Medicine.
High Frequency of Drug-Impacting Gene Variants Found in All of Us Cohort
A study finds that everyone in a diverse, nearly 100,000-person sample carried at least one genetic variant that affects how their body processes medications, and a quarter of those people had been prescribed a medication that is known to be impacted by the variant they carried. The post High Frequency of Drug-Impacting Gene Variants Found in <i>All of Us</i> Cohort appeared first on GEN - Genetic Engineering and Biotechnology News.
You likely have genes that affect how well your medications work – testing for them could improve treatment
by Philip Empey, University of Pittsburgh, [This article first appeared in The Conversation, republished with permission]a All people carry differences in their DNA that could affect how they respond to...
A study has found that genetic differences may be one of the reasons why medication does not produce the expected results or causes unexpected side effects. According to Medical Express on the 11th (local time), researchers at the University of Pittsburgh analyzed the genomes of approximately 100,000 American adults and found that every subject possessed at least one genetic variant that could affect the drug processing process. The research r…
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