Robert Kolker in The New York Times:
The story of the science of dementia began on an autumn day in 1891, when a 71-year-old man was admitted to the psychiatric hospital at the University of Prague. The man, referred to as August H. in his medical file, had periods of freezing up mentally, sometimes fainting and not coming to for several minutes. More recently, he had been prone to fits of rage, and even threatened his wife with a knife, shouti…
Since the time of Dr. Alzheimer himself, there has been a dream that severe senility could have an explanation and a cure. The search for both is now more urgent than ever.