US EditionUniversity of Pennsylvania Study Flags Underreported GLP-1 Side Effects on Reddit
AI analysis of 400,000 Reddit posts found 43.5% of 67,008 users reported side effects, including menstrual changes and temperature-related symptoms.
- Researchers from the University of Pennsylvania published a study in Nature Health using artificial intelligence to analyze over 400,000 Reddit posts, identifying patient-reported side effects of GLP-1 receptor agonists that clinical trials may have missed.
- While GLP-1 receptor agonists have soared in popularity for managing blood sugar and weight loss, adverse events remain a common cause of discontinuing the drug, with the MHRA previously highlighting gastrointestinal complaints.
- Of the nearly 70,000 users analyzed, 43.5 per cent reported at least one side effect, with nausea at 36.9 per cent, fatigue at 16.7 per cent, vomiting at 16.3 per cent, constipation at 15.3 per cent, and diarrhoea at 12.6 per cent.
- Lead author Neil Sehgal told Medical News Today that "nearly 4% of users who reported side effects mentioned menstrual changes," noting these reproductive symptoms are not prominently featured in current prescribing information.
- Researchers emphasize these findings do not prove causation, only that users reported symptoms while taking medications; the team hopes to expand future research beyond Reddit to include more diverse populations and English-language data.
13 Articles
13 Articles
An analysis of more than 400,000 publications in Reddit triggered alerts about possible side effects of drugs such as Ozempic, Wegovy and Moungaro. The research identified symptoms that do not always appear in clinical trials or regulatory documents. The study, developed by researchers at the University of Pennsylvania and published at Nature Health, reviewed more than five years of publications from about 70,000 users. Scientists found two grou…
Ozempic and Mounjaro linked to possible 'unrecognised' side effects in study of 70,000 users
Weight-loss injections such as Ozempic and Mounjaro may cause side effects that pharmaceutical companies have not included on their official labels, according to new research.An analysis published in the journal Nature Health has revealed menstrual irregularities and temperature-related complaints, including chills and hot flushes, have emerged as potential effects not currently recognised in clinical documentation.American scientists examined p…
GLP-1 medicine improves liver health independent of weight loss, study finds
Researchers at Toronto's Sinai Health have found that semaglutide—the active ingredient in popular weight loss drugs that mimic the gut hormone GLP-1—acts directly on a subset of liver cells to improve organ function and does so independently of weight loss. The finding challenges long-held assumptions about how GLP-1 medicines work in the liver and could reshape how physicians treat metabolic liver disease.
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