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UK Trials First Ebola Vaccine Using COVID-19 Platform
The Phase 1 study will test safety and immune response in 50 healthy adults, with larger trials planned if results are positive.
On Monday, the University of Oxford launched the first human trial of a vaccine against Bundibugyo ebolavirus, seeking to combat the outbreak spreading in the Democratic Republic of Congo and Uganda.
The Bundibugyo species has caused two previous outbreaks and currently spreads through Congo, where confirmed cases rose to 1,926, including 702 deaths, the country's public health institute said on Monday.
Scientists at the Oxford Vaccine Group and Pandemic Sciences Institute developed the shot using the same viral vector platform as the AstraZeneca Covid vaccine; the Serum Institute of India stockpiled around 620,000 doses.
The early-stage trial, known as BD-Ebov, will evaluate safety and immune response in 50 healthy adults aged 18 to 55, with The Coalition for Epidemic Preparedness Innovations investing up to $8.6 million.
Chief investigator Dr. Katrina Pollock noted that Ebola species are "sisters rather than twins," requiring distinct vaccines; researchers plan further clinical studies in Uganda with year-long volunteer monitoring.