Why Were Psychedelic Trials Hard to Blind?

Why were psychedelic trials hard to blind?

The blinding problem in psychedelic research Multiple trials of psychedelic assisted mental health interventions have struggled with one basic methodological step: blinding. In studies of psilocybin, LSD, and DMT, participants could often tell whether they had received a psychedelic or a placebo.…

Trials of psychedelics for mental health may be invalid, because it's fairly obvious to patients whether they've been given a psychedelic or a placebo. Blinding failed more than 90% of the time in the studies of psilocybin, LSD and DMT, and 85% of the tim