Three-layer model maps how protein-modifying enzymes may help regulate immunity

Three-layer model maps how protein-modifying enzymes may help regulate immunity

Researchers at the University of Tsukuba have proposed a "three-tiered proteostasis model" for describing immune regulation by protein arginine methyltransferases (PRMTs), comprising protein arginine methylation, free methylarginine generation from protein turnover and methyltransferase-independent interactions with RNA and proteins. The framework integrates emerging evidence linking PRMTs to immune regulation, metabolism, vascular function and …