Massive Atlas of Brain Region Linked to a Host of Diseases Is the Most Detailed Yet
Researchers profiled more than 25 million cells and found cell types tied to depression, bipolar disorder and schizophrenia.
- On Thursday, neuroscientist Hongkui Zeng, director of brain science at the Allen Institute, and researchers published the first cross-species cellular atlas of the basal ganglia in 26 papers across Cell journals.
- Essential for movement, habit formation, and emotion, the basal ganglia are linked to Parkinson's disease and schizophrenia; researchers previously relied on mouse and monkey models to study these brain structures.
- The atlas comprises 25.5 million brain cells from humans, macaques, and marmosets, enabling researchers to identify 61 conserved cell types across 76 million years of primate evolution.
- Zeng described the data as a 'parts list' that helps researchers identify cell-type-specific targets for gene therapy, potentially improving precision treatments for neurodegenerative diseases.
- Part of the US$500-million BRAIN Initiative Cell Atlas Network, this collaboration aims to map the entire human brain by 2028, establishing a comprehensive reference for future research.
14 Articles
14 Articles
The most detailed map to date of basal ganglia collects data from humans and other primates could help to better understand diseases such as Parkinson's disease or schizophrenia.
Cellular atlas created for the basal ganglia, a key brain region
An international consortium presents the most detailed cellular atlas of basal ganglia, where there are hidden keys to the main brain ailments
An international neuroscience project succeeds in creating the first three-dimensional cellular atlas of human basal ganglia, an essential region for movement, behavior and emotions
Researchers have created a detailed cellular map of a key part of our brain, the basal ganglia. This key brain region is responsible for movement, decision-making, emotions, and habit formation, among other things. The new cellular atlas could help develop more effective treatments for a number of serious neurological and psychiatric diseases.
New research focuses on basal ganglia, a complex and deep network of brain regions involved in movement, behavior and decision-making Read
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