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Rapid Tau Spread May Explain Why Midlife Alzheimer's Progresses More Rapidly

Summary by Medical Xpress
Patients with early-onset Alzheimer's disease, whose symptoms start before age 65, have more extensive deposits of tau, a hallmark protein of the condition, compared with patients whose symptoms start at 65-plus, a new study found. What's more, tau accumulates at more than twice the rate in younger compared to older patients and spreads widely throughout the brain.

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A study has found that patients whose Alzheimer's symptoms began before age 65 accumulate 'tau protein,' a pathological protein in the brain, at more than twice the rate compared to patients who developed the disease after age 65, and the extent of brain invasion is also wider. According to Medical Express on the 4th (local time), a research team from the University of California, San Francisco, published these findings in the international jou…

Research published in the journal Science Translational Medicine identified greater accumulation and dissemination of tau protein in patients under 65 years of age. About one in five initially presents problems of vision, language or behavior. Early onset Alzheimer's, diagnosed before 65 years of age, may present a more aggressive and rapid evolution of [...]

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Medical Xpress broke the news in Douglas, United Kingdom on Wednesday, November 4, 2026.
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