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Study: Women Starting Hormone Therapy In Their 50s May Lower Dementia Risk
Researchers said women who began hormone replacement therapy in midlife saw the biggest benefit, with a 16% lower Alzheimer’s disease risk.
A new study analyzed Biobank data of 183,450 postmenopausal Women, finding HRT use associated with a 10% lower risk of all-cause dementia and a 16% lower risk of Alzheimer disease over 13 years.
Women who started HRT between ages 46 and 56 experienced the greatest reduction in dementia risk, with stronger associations among those with surgical menopause or carrying the APOE4 gene.
Hall explained that Women commonly report HRT helps brain function at any age up to 90, suggesting potential benefits that extend beyond dementia risk reduction alone.
Trinh noted that because this was an observational study, it cannot prove HRT itself prevents dementia, and he cautioned against starting treatment solely for prevention based on these findings.
Future research should employ randomized studies separating hormone formulations and stratifying participants by APOE genotype, Trinh added, to determine which Women benefit most from therapy.