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Study: Women Starting Hormone Therapy In Their 50s May Lower Dementia Risk

Researchers said women who began hormone replacement therapy in midlife saw the biggest benefit, with a 16% lower Alzheimer’s disease risk.

  • A new study analyzed Biobank data of 183,450 postmenopausal Women, finding HRT use associated with a 10% lower risk of all-cause dementia and a 16% lower risk of Alzheimer disease over 13 years.
  • Women who started HRT between ages 46 and 56 experienced the greatest reduction in dementia risk, with stronger associations among those with surgical menopause or carrying the APOE4 gene.
  • Hall explained that Women commonly report HRT helps brain function at any age up to 90, suggesting potential benefits that extend beyond dementia risk reduction alone.
  • Trinh noted that because this was an observational study, it cannot prove HRT itself prevents dementia, and he cautioned against starting treatment solely for prevention based on these findings.
  • Future research should employ randomized studies separating hormone formulations and stratifying participants by APOE genotype, Trinh added, to determine which Women benefit most from therapy.
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studyfinds.com broke the news on Monday, August 31, 2026.
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