Tau Protein Can Sneak Into Brain Cells’ Energy Factories—and Wreak Havoc

Study uncovers how brain cells coordinate movement planning

Which neurons in the brain control movements, and how? This question was addressed by a team of researchers from the fields of neuroscience and artificial intelligence in a study conducted on an animal model at the interdisciplinary research centre BrainLinks-BrainTools at the University of Freiburg.

Tau protein can sneak into brain cells’ energy factories—and wreak havoc

Study of mitochondria suggests new treatment strategy for Alzheimer’s and other diseases

Tau protein linked to Alzheimer’s disrupts nerve cells’

A newly identified mechanism may explain how tau protein helps drive Alzheimer’s disease and other tauopathies, according to research from Stanford Medicine. Rather than acting primarily through the formation of neurofibrillary tangles or the destabilization of microtubules, chemically modified tau appears to enter mitochondria and disrupt the organelles’ energy-generating machinery. The resulting metabolic failure triggers a destructive cycle i…

Tau Protein Linked to Mitochondrial Reverse Electron Transport in Preclinical Models

Studies by researchers at Stanford University School of Medicine and at the University of California, San Francisco, have found that the protein tau, which is implicated in neurodegenerative disorders including Alzheimer’s disease, may be linked to these such disorders in a way that differs greatly from the pathological pathway usually ascribed to it. Hyperphosphorylation and aggregation of tau are hallmarks of primary and secondary tauopathies …