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Nature Study Proposes Clinical and Preclinical Obesity Categories

Researchers say waist measures and organ dysfunction improve diagnosis, with 23% to 31% of obesity cases classified as clinical obesity.

  • On Wednesday, King's College London researchers published a study in Nature testing a diagnostic framework that adds waist circumference and body-fat measurements to BMI across 844,108 adults from four countries.
  • BMI alone is a blunt measure that ignores fat distribution and organ dysfunction. The new framework distinguishes 'pre-clinical obesity' and 'clinical obesity' to enable personalized, proportionate treatment based on individual health risks.
  • Results show BMI overestimated obesity in up to 3.1% of people and underestimated it in up to 8.6%, potentially flipping diagnoses for millions and increasing overall prevalence by up to 7.4% versus BMI alone.
  • Clinical obesity carries a 69% higher death risk than people without obesity or organ dysfunction, whereas pre-clinical obesity showed a 19% increase. Roughly 82% of pre-clinical cases did not progress to clinical obesity over a decade.
  • Professor Francesco Rubino, the study's senior author, stated the framework aims to "provide a meaningful clinical characterization of obesity that can inform care and policy," with treatment intensity matched to individual health risks.
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Center

A new diagnostic method is much more accurate than the traditional body mass index (BMI) in identifying obese and health-risk patients, the effectiveness of which was supported by a recent study published in the journal Nature, Live Science reported.

·Budapest, Hungary
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Lean Left

New study offers support for the newer view that obesity should not be defined solely based on height and weight. The post Most “obese” people are actually healthy – Time to change the definition appeared first on in.gr.

·Greece
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Lean Right

In the calculation of the body mass index, size and weight are included. However, this is insufficient, a recent study shows. The reason: the harmful belly fat is overlooked. The researchers therefore propose a new method of calculation.

Millions of patients are currently misdiagnosed based on their body mass index, a new international study suggests. Researchers are therefore recommending that doctors look at waist circumference and visceral data in addition to their weight to distinguish between body composition and actual disease.

·Tallinn, Estonia
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Center

The body mass index (BMI) is undoubtedly one of the most commonly used tools for diagnosing obesity. However, this indicator, which relates weight to a person's height, does not allow to distinguish between fat and muscle or to know in which parts of the body fat accumulates. These limitations can lead to overestimation or underestimation of obesity and, consequently, the risks it poses to health.

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Nature broke the news in London, United Kingdom on Wednesday, November 11, 2026.
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