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Study: Psilocybin Shows Potential Promise in Treating Cocaine Addiction

Researchers found psilocybin with psychotherapy led to more cocaine-free days and 30% complete abstinence at 180 days, the study said.

  • A new study published in JAMA Network Open reveals a single dose of psilocybin combined with psychotherapy significantly increased cocaine abstinence in patients with cocaine use disorder.
  • Targeting historically underrepresented groups, the trial enrolled 40 participants—mostly Black men earning less than $20,000 annually—to address the lack of FDA-approved pharmacological treatments for cocaine use disorder.
  • Results showed 30% of psilocybin recipients achieved complete abstinence through 180 days, compared to 0% in the placebo group, with no serious adverse events reported.
  • Lead investigator Peter Hendricks, professor in the Department of Psychiatry and Behavioral Neurobiology, stated results are promising but require larger, multisite trials to confirm broader applicability.
  • These clinical findings emerge amid an expanding federal push to accelerate psychedelic research, including President Donald Trump's April 18 executive order facilitating access to psychedelic drugs for eligible patients.
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It is psilocybin, a promising fungal derivative against the disorder.Researchers from the USA, Britain and Sweden successfully tested it in volunteers. 30% still did not use cocaine 180 days after the dose of the drug received.

·Buenos Aires, Argentina
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Science broke the news on Thursday, May 7, 2026.
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