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Study: Cancer Jab Eliminates Tumors in Patients
Researchers said the injection erased tumours in 15 patients and helped 42% of trial participants, offering a new option after chemotherapy and immunotherapy failed.
On Sunday, researchers will present results at the American Society of Clinical Oncology meeting in Chicago showing amivantamab shrank or eradicated head and neck tumours in 43 of 102 patients, including 15 complete responses.
This triple-action jab blocks EGFR and MET pathways while activating the immune system, targeting HPV-negative head and neck cancers that typically resist standard chemotherapy and immunotherapy.
Carl Walsh joined the OrigAMI-4 trial at the Royal Marsden in July 2025, reporting his diet and speech returned to normal; most patients experienced mild side-effects, with fewer than one in 10 stopping treatment.
Describing the responses as 'unprecedented,' Kevin Harrington, professor in biological cancer therapies at the Institute of Cancer Research, noted this represents a significant step forward for thousands of patients annually.
Johnson is evaluating amivantamab in about 60 clinical trials across multiple cancer types, with similar results reported in lung cancer, signaling potential to extend beyond current head and neck applications.
Doctors praised the "unprecedented" results of a clinical trial in 11 countries demonstrating that a triple injection against cancer can eradicate whole tumours in patients.