US EditionStrokes can cause debilitating damage. Two UConn researchers have found a way to limit it
The experimental drug targets microRNA to reduce brain damage and inflammation after stroke, with a $2.6 million NIH grant supporting its development for improved recovery.
- Researchers at UConn are working on a novel medication aimed at safeguarding the brain and enhancing recovery following stroke incidents in the United States.
- This effort arises because current stroke therapies, including clot-busting drugs and surgical removal, reach only 10 to 15% of patients and no FDA-approved drugs protect brain recovery.
- The researchers targeted microRNA, a small regulatory molecule that rises abnormally after stroke and promotes inflammation, tissue loss, and neurological decline.
- They developed a next-generation miRNA inhibitor that blocks harmful effects by simultaneously suppressing multiple proteins, with a single dose reducing brain damage and improving recovery up to 15 days in mice.
- The team received a $2.6 million NIH grant for five years, filed a patent, and is working with partners to develop the inhibitor into a clinical trial candidate.
25 Articles
25 Articles
Strokes can cause debilitating damage. Researchers have found a way to limit it
With limited treatment options for stroke patients available, two UConn researchers are developing an experimental drug that is capable of protecting the brain and improving recovery after a cerebral vascular accident also known as a brain attack.
Researchers may have found a way to limit the debilitating damage strokes can cause
With limited treatment options for stroke patients available, two UConn researchers are developing an experimental drug that is capable of protecting the brain and improving recovery after a cerebral vascular accident also known as a brain attack.
LA Daily News
Strokes can cause debilitating damage. Two UConn researchers have found a way to limit it
With limited treatment options for stroke patients available, two UConn researchers are developing an experimental drug that is capable of protecting the brain and improving recovery after a cerebral vascular accident also known as a brain attack. Rajkumar Verma, assistant professor at UConn Health who leads a research program for advancing innovative therapies for stroke, and Raman Bahal, associate professor in the Department of Pharmaceutical …
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