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Scientists discover never-before-seen part of human cells

  • In May 2025, University of Virginia and NIH scientists discovered the hemifusome, a new organelle in human cells, published in Nature Communications.
  • Limitations of traditional imaging methods hindered observation of the hemifusome, but cryo-electron tomography preserved cells in a native state, enabling its discovery, as Ebrahim stated: 'We would have missed this.'
  • Researchers identified hundreds of hemifusomes in four mammalian cell types, constituting nearly 10% of all membrane-bound vesicles, across multiple cell regions.
  • Understanding hemifusomes could unlock new insights into Alzheimer's progression and lead to future treatments targeting cellular protein management.
  • Expanding on this work, researchers will investigate hemifusome behavior in healthy and diseased cells to explore potential treatments for genetic conditions.
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At the heart of our cells, an unprecedented structure has just been identified, illuminating by a new day the essential biological mechanisms. This discovery could transform our...

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Live Science broke the news in United States on Monday, June 30, 2025.
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