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Experts Say RSV Antibody Shot Is Safe for Babies with Vaccinated Moms

A study of 181 mother-infant pairs found no serious side effects from RSV antibody shots after maternal vaccination, with babies showing high antibody levels, researchers said.

  • Researchers found that nirsevimab can be given to infants whose mothers were vaccinated during pregnancy without serious adverse effects.
  • Sunday at IDWeek in Atlanta, researchers said prior studies had not tested antibody shots for babies after maternal RSV vaccination, highlighting a key evidence gap presented at the joint infectious disease meeting.
  • Researchers analyzed 181 mother/infant pairs from eight hospitals across the United States, evenly representing three prevention approaches, with ongoing immune durability one-year follow-up and breast milk antibody testing.
  • Dr. Christina Rostad said the findings reassure parents that all RSV immunization methods yield high antibody levels, with infants of unvaccinated mothers showing a larger response. Babies can safely receive nirsevimab after birth even if their mothers were vaccinated during pregnancy.
  • This first post-approval season saw about 43% of infants receive nirsevimab, while 68% of mothers did not get prenatal RSV vaccine and about 28% of infants had no RSV immunization.
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RSV Antibody Shot Safe For Infants Even If Mom Was Vaccinated During Pregnancy, Experts Say

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Medical Xpress broke the news in on Monday, October 20, 2025.
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