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‘Best Medicine’: Josh Charles & Boss Talk Martin’s Blood Phobia, Opening up to Louisa & More

The Fox series reimagines the British original with a Maine setting and new storylines, featuring Josh Charles as Dr. Martin Best in a small-town medical comedy.

  • Fox premieres Best Medicine on Jan. 4 at 8 p.m. ET, with remaining episodes airing Tuesdays at 8 p.m. ET starting Jan. 6; the series remakes the U.K. Doc Martin and depicts Port Wenn, Maine using Cornwall, N.Y.
  • Developed by Liz Tuccillo, the adaptation reshapes the lead's origin as Tuccillo added a childhood trauma to Dr. Martin Best, aligning with U.S. television industry practice of remakes.
  • Josh Charles leads a cast including Abigail Spencer and Annie Potts, with Josh Segarra and a gay couple owning a pet pig named Brisket enriching the Port Wenn setting.
  • Reviewers note the tonal softening compared with the U.K. original as Josh Charles plays a gentler doctor than Martin Clunes, with several supporting roles receiving limited development amid a whimsical tone.
  • Because Doc Martin is widely available on U.S. platforms, comparisons begin immediately as the original ran multiple seasons and the adaptation may shape the U.S. adaptations trend.
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‘Best Medicine’: Josh Charles & Boss Talk Martin’s Blood Phobia, Opening up to Louisa & More

The new Fox medical dramedy is based on the U.K.'s 'Doc Martin.'

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staytunedmag.com broke the news in on Sunday, January 4, 2026.
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