Researchers Discover a Key Gene that Controls the Development of Cells Involved in Memory and Learning

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A study by the Cajal-CSIC Center of Neurosciences in Madrid revealed a new mechanism that regulates how adult neural stem cells are generated in the denture of the hippocampus, a region linked to memory and learning. Research in mice shows that the Sox5 gene is essential to keep these cells in a balanced state of rest. These neural stem cells remain in a state called quiescence, in which they do not mature or divide, but can be activated when ne…

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A research by the Cajal-CSIC Center of Neurosciences in Madrid has discovered a new mechanism that controls how adult neural stem cells are generated during the development of toothed rotation, a region of the hippocampus key in memory and learning. Specifically, they have found out how neural stem cells (progenitors of neurons) alternate between rest and activation, an essential requirement to preserve the regenerative capacity of the brain thr…

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In particular, they have found out how neural stem cells (progenitors of neurons) alternate between rest and activation, an essential requirement to preserve the regenerative capacity of the brain throughout life. The finding, published in the journal PLOS Biology, points to the Sox5 gene as “guardian” of this cellular balance. The study, led by Dr. Aixa Morales, responsible for the Molecular Control Laboratory of Neurogenesis, has been carried …

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A research by the Cajal-CSIC Center of Neurosciences in Madrid has discovered a new mechanism (the 'Sox5' gene) that controls how adult neural stem cells are generated during the development of toothed rotation, a region of the hippocampus involved in memory and learning.