US EditionFreeze-Framing the Cellular World to Capture a Fleeting Moment of Activity
The technique freezes dynamic cellular events at precise timepoints, improving measurement accuracy by allowing exposure times 1,000 times longer than conventional live-cell imaging, researchers said.
3 Articles
3 Articles
Push pause to capture high-resolution snapshots of cells
Rapid freezing of intracellular calcium ion propagation happens in milliseconds. Credit: 2025, Kosuke Tsuji, Masahito Yamanaka et al., Time-deterministic cryo-optical microscopy, Light:Science&Applications Researchers have observed accurate, high-resolution snapshots of cell activity at a precisely chosen moment using a new cryo-optical microscopy technique. This novel method offers new possibilities for observing fast, dynamic cellular events, …
Freeze-framing the cellular world to capture a fleeting moment of activity
Optical microscopy is a key technique for understanding dynamic biological processes in cells, but observing these high-speed cellular dynamics accurately, at high spatial resolution, has long been a formidable task.
Optical microscopy is a key technique for understanding dynamic biological processes in cells, but the observation of these high-speed cellular dynamics with precision, with high spatial resolution, has long been a formidable task. Now, in an article published in Light: Science and Applications by researchers at the University of Osaka, as well as institutions [...]
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