Rat Kidneys Grown in Mice Offer New Hope for Transplant Patients
The embryos did not survive to birth, but the study points to a possible path for transplantable organs as kidney demand reaches 5 million by 2030.
- Researchers in Japan generated rat-derived kidneys in mouse embryos using interspecies blastocyst complementation, a technique published in Stem Cell Reports that creates genetically kidney-deficient mice.
- With demand for kidney transplants expected to reach 5 million patients by 2030 and only a fraction of current need being met, scientists are exploring innovative approaches to generate transplantable organs.
- Dr. Shunsuke Yuri of the National Center for Geriatrics and Gerontology in Obu City stated rat embryonic stem cells contributed extensively to kidney formation, including nephron progenitor cells and ureteric bud lineages.
- Although the interspecies embryos did not survive to birth, preventing assessment of kidney function, Yuri noted the study demonstrates the potential of using one species to generate organs from another.
- Ayako Isotani of the Nara Institute of Science and Technology stated the findings represent an important step toward growing transplantable human organs in larger animals, addressing the global donor shortage.
29 Articles
29 Articles
Interspecies blastocyst complementation generates generates rat-derived kidneys in mice
Kidney transplantation remains the most effective treatment for end-stage kidney disease, yet a severe shortage of donor organs continues to limit access for millions of patients worldwide.
Rat kidneys grown in mice offer new insights into addressing organ donor shortages
Kidney transplantation remains the most effective treatment for end-stage kidney disease, yet a severe shortage of donor organs continues to limit access for millions of patients worldwide. With demand for kidney transplants expected to reach 5 million patients by 2030 and only a fraction of that need currently being met, researchers are exploring innovative approaches to generate transplantable organs.
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Rat kidneys grown in mice offer new hope for transplant patients
Japanese scientists the breakthrough provides a new way of helping to reduce growing organ donor shortages.
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