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Many Breast Cancer Patients Don't Need Radiation After Mastectomy
An international trial led by the University of Edinburgh found 10-year survival rates were similar with or without radiotherapy for intermediate-risk breast cancer patients post-mastectomy.
- The SUPREMO trial, led from the University of Edinburgh, shows many mastectomy patients on modern anti-cancer therapy can omit chest-wall radiotherapy without compromising outcomes, published Nov. 5 in the New England Journal of Medicine.
- Because earlier evidence left a gap for intermediate-risk patients, chest-wall radiotherapy after mastectomy relied on 1980s clinical trials, causing uncertainty and varied worldwide use.
- The trial randomised 1,607 patients, assigning 808 women to radiotherapy and 799 to no radiotherapy, with 10-year overall survival at 81.4% and 81.9% and 29 chest-wall recurrences total, nine in radiotherapy arm.
- Experts say the findings should reshape treatment discussions for many patients qualifying for radiotherapy under existing guidelines, avoiding unnecessary radiotherapy to reduce treatment burden and protect breast reconstruction outcomes, while specialists caution radiation remains important for higher-risk patients.
- The international research team, including scientists from the UK, Netherlands, Australia and China, conducted the trial funded by Medical Research Council and National Institute for Health and Care Research.
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10-Year Study Finds Radiation Doesn’t Improve Survival in Early-Stage Breast Cancer
Medical Radiology Techniques for Imaging and Radiotherapy. Credit: Università Campus Bio-Medico di Roma – CC BY-NC-SA 2.0 via Flickr. A large international study conducted over 10 years found that radiation therapy after mastectomy did not improve survival for women with early-stage breast cancer considered at ‘intermediate risk,’ calling into question a long-standing component of post-surgical treatment for many patients. Researchers followed m…
Radiation may be unnecessary as an early-stage breast cancer treatment
Radiation for early-stage breast cancer may not be necessary, new research suggests. Women who received a radiation course after a mastectomy essentially had the same 10-year survival rate at those who did not receive radiation, a study shows.
·Philadelphia, United States
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Total News Sources23
Leaning Left5Leaning Right3Center7Last UpdatedBias Distribution47% Center
Bias Distribution
- 47% of the sources are Center
47% Center
L 33%
C 47%
R 20%
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