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Psychedelics may be no better than antidepressants for depression

Researchers found psychedelic-assisted therapy's advantage over antidepressants is minimal after correcting for unblinding; antidepressants outperformed by only 0.3 points on depression scales.

Summary by NewScientist
Drugs like psilocybin that induce psychedelic effects have shown promise for treating depression. Now, a review of the evidence suggests that they are effective, but no more so than traditional antidepressants

5 Articles

Psilocybin, a miracle medicine? The most comprehensive German study to date now shows that even psychedelic drugs can't help everyone – but some can.

·Munich, Germany
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Mannheim/Berlin – A randomized, triple-blind, phase 2b trial from Germany provides evidence for a possible antidepressant effect of psilocybin in treatment-resistant depression – however, the primary endpoint was not met (JAMA Psychiatry 2026; DOI: 10.1001/jamapsychiatry.2026.0132). The study was conducted at the Central Institute for...

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scimex.org broke the news in on Wednesday, March 18, 2026.
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