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Prisco's Week 17 NFL picks: Bills vs. Eagles prediction and more best bets

Pete Prisco’s NFL picks analyze quarterback injuries and playoff motivation affecting Week 17 outcomes with a 124-114-2 ATS record, aiming for a strong finish.

Summary by CBS Sports
Pete Prisco reveals all of his Week 17 picks, including key wins by the Chargers, Jaguars and 49ers.
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CBS SportsCBS Sports
Center

Prisco's Week 17 NFL picks: Bills vs. Eagles prediction and more best bets

Pete Prisco reveals all of his Week 17 picks, including key wins by the Chargers, Jaguars and 49ers.

·United States
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Sporting NewsSporting News
Center

NFL picks, predictions against the spread Week 17: Eagles edge Bills, Steelers stymie Browns, 49ers cool Bears

In Sporting News' Week 17 picks against the spread, Philadelphia wins at Buffalo, Pittsburgh goes well into Cleveland and the 49ers win in Chicago.

·North Carolina, United States
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USA TodayUSA Today
Lean Left

Eagles at Bills: Predictions, picks and odds for NFL Week 17 game

USA Today's NFL experts make their picks for a Week 17 showdown between the Buffalo Bills and Philadelphia Eagles

·United States
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USA Today broke the news in United States on Wednesday, December 24, 2025.
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