Novel CRISPR-Cas9 BAP1 Knockout Pre-Clinical Tumor Model Recapitulates Human Melanoma Tumorigenesis and Immune Evolution

CRISPR- Cas9: A Promising Tool against antibiotic-resistant bacterial infections

Breaking down the microbiology world one bite at a time HomeAbout usMicroBitesThe teamArchivesVolunteeringContactNewsletter CRISPR- Cas9: A Promising Tool against antibiotic-resistant bacterial infections  Written bymeenatekkalakote24 Antibiotic-resistant bacterial infections are a growing global crisis, causing millions of deaths worldwide. Bacteria develop resistance through two main mechanisms: random mutations in their DNA or acquiring resis…

Novel CRISPR-Cas9 BAP1 Knockout Pre-Clinical Tumor Model Recapitulates Human Melanoma Tumorigenesis and Immune Evolution

BAP1-deficient melanocytic tumors exhibit strong immunosuppressive features and poor prognosis. Currently, no immune-competent preclinical models exist to study their tumor-immune interactions or test new immunotherapies. This limitation hinders progress in understanding how BAP1 loss drives tumo...