49ers Get NFL’s Strongest Week 2 Vote of Confidence vs. Dolphins

49ers Get NFL’s Strongest Week 2 Vote of Confidence vs. Dolphins

The 49ers opened as huge favorites over the Dolphins in Week 2, the NFL’s biggest opening spread after San Francisco’s dominant Week 1 win.

Analysts' early Week 2 plays after Week 1 odds came out

With most of Week 1 complete, attention has turned to Week 2 lines. The Buffalo Bills will open their new stadium Thursday night against the Detroit Lions in a game carrying the highest total of the young season at 53.5, and the largest spread belongs to the San Francisco 49ers hosting the Miami Dolphins. Week […]

NFL Week 2 ATS Picks & Predictions - Early Lines to Target

Week 1 is still on the go but NFL Week 2 odds have already been posted, offering bettors a fresh slate of lines to dissect. The action kicks off on Thursday, September 17, at 8:15 PM ET when the Detroit Lions visit the Buffalo Bills, and wraps up Monday, September 21, at 8:15 PM ET … Continued

2026 NFL Odds Week 2: Lines, Spreads, Results For All 16 Games

Check out the early odds, spreads and totals for all 16 Week 2 games.