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New Progress -- XellSmart Unveiled Phase I Results of Off-the-Shelf Parkinson's Disease Cell Therapy at MDS & Completed Blinded Phase II Enrollment
XellSmart presented Phase I data for its off-the-shelf Parkinson’s disease cell therapy, XS411, at the International Congress of Parkinson’s Disease and Movement Disorders.
¹⁸F-DOPA PET imaging showed increased tracer uptake at the transplant site after XS411 treatment, indicating higher regional dopamine synthesis and metabolic capacity.
The trial met its primary safety and tolerability goals, and XS411 was generally well tolerated.
At six months, participants’ average OFF-state motor scores improved by more than 30 points, while daily good ON time increased by over five hours; all 30 planned participants were enrolled.