US EditionNew Oral Gene Therapy Made Possible by Colorectal Cancer Findings
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New Oral Gene Therapy Made Possible by Colorectal Cancer Findings
A study reports a discovery that opens up a new path into treating colorectal cancer (CRC), which is notoriously resilient, with chemoresistance and immunosuppression often standing in the way of effective treatments. Wuhan University scientists identified the mitochondrial protein TRAP1 as a key player in CRC’s defenses and disrupted its gene by developing an advanced oral CRISPR–Cas9 delivery system. Encased in nanocomplexes, this system navig…
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