US EditionNew Drug Could Quell Uncontrolled High Blood Pressure
- Researchers reported on May 5, 2025, that an experimental drug, lorundrostat, reduced high blood pressure more than placebo in a clinical trial.
- The trial involved 285 patients with hypertension uncontrolled by two to five medications, targeting aldosterone which drives persistent high blood pressure.
- Approximately two-thirds of the participants treated with lorundrostat for 12 weeks saw their systolic blood pressure decrease by 15 points, compared to a 7-point reduction in the placebo group, although some patients still had elevated blood pressure levels.
- Principal investigator Dr. Michael Wilkinson explained that the study focused on a novel method targeting aldosterone imbalances, an often overlooked factor in resistant hypertension, and highlighted that the treatment was effective in reducing systolic blood pressure.
- Researchers believe these encouraging findings may pave the way for a subsequent Phase III study that would support a potential FDA approval, providing a new treatment option for patients with resistant hypertension.
45 Articles
45 Articles
Morning high blood pressure - what could be the cause?
Blood pressure varies to a lesser extent throughout the day, usually higher in the morning than at other times of the day. However, in addition to natural fluctuations, there are some factors that can lead to high morning blood pressure, which must be treated. Dr. Zsigmond Máté Jenei, an internist and cardiologist at the Cardiology Center, listed the most common causes.
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New Drug Could Quell Uncontrolled High Blood Pressure
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How to reduce high blood pressure death risk
High blood pressure, or hypertension, affects over one-third of adults around the world and is a major cause of early death due to heart disease, stroke, and other long-term health problems. Even though there are many medicines and treatments to lower blood pressure, people with hypertension still face high risks if other health issues—like obesity, […] The post How to reduce high blood pressure death risk appeared first on Knowridge Science Rep…
Clinical outcomes of out-of-office versus in-office blood pressure monitoring in adults with hypertension
Clinical outcomes of out-of-office versus in-office blood pressure monitoring in adults with hypertension This is a protocol for a Cochrane Review (intervention). The objectives are as follows: To assess the effects of out-of-office compared to in-office blood pressure (BP) monitoring for improving clinical outcomes in adults with hypertension. This is a protocol....
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