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New Bio-Inspired Gel Helps Tooth Enamel Grow Back
The fluoride-free gel restores enamel by mimicking natural proteins and can regenerate layers up to 10 micrometers, potentially easing tooth sensitivity and decay, researchers say.
- THURSDAY, Dec. 18, 2025: University of Nottingham researchers unveiled a fluoride-free protein-based gel that regenerates damaged tooth enamel by mimicking enamel-building proteins.
- Because natural enamel cannot regrow, losing enamel exposes inner tooth layers, increasing risk of tooth decay, while interest in fluoride-free options grows amid ingestible fluoride debate in the United States.
- Electron microscopy images showed eroded apatite crystals transformed into regenerated enamel crystals after two weeks on 32 extracted human molar teeth, demonstrating epitaxial mineralization.
- The gel could restore thin surface layers up to about 10 micrometers, and growing an enamel-like layer on dentine may relieve hypersensitivity while improving restorations.
- Earlier this year the team launched Mintech-Bio with commercial aims, and the findings published recently in Nature Communications showed regenerated enamel performed like natural enamel, signaling real-world durability.
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Total News Sources20
Leaning Left4Leaning Right2Center6Last UpdatedBias Distribution50% Center
Bias Distribution
- 50% of the sources are Center
50% Center
L 33%
C 50%
R 17%
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