Nanovaccine design boosts immune attack on HPV tumors

Nanovaccine design boosts immune attack on HPV tumors

Throughout the past decade, Northwestern University scientists have uncovered a striking principle of vaccine design: Performance depends not only on vaccine components but also on vaccine structure.

Cancer vaccine shows promise against HPV-related throat tumors in early study

If proven effective in humans, the vaccine could complement standard therapies for HPV-driven cancer, as well as inform the design of therapeutic vaccines for other diseases.

Scientists Supercharge HPV Cancer Vaccine With a Tiny Structural Shift

A tiny structural tweak turned a modest cancer vaccine into a tumor-fighting powerhouse. Over the past 10 years, researchers at Northwestern University have uncovered an important lesson about vaccine design. What a vaccine is made of matters, but how those ingredients are arranged can be just as critical. After confirming this principle in multiple studies, [...]

HPV cancer vaccine slows tumor growth, extends survival in preclinical model

Scientists designed vaccines to treat HPV-positive head and neck cancer. All vaccines had the same ingredients but different, strategically designed structures. One vaccine vastly outperformed the others, showing that vaccine design depends on structure as well as medicinal components.