Space-Grown Glioblastoma Organoids Could Help Advance Brain Cancer Treatments

Space-grown organoids better replicate aggressive glioblastoma tumors

Glioblastoma (GBM) is the most common malignant primary brain tumor in adults and is one of the most aggressive and deadly forms of cancer.

Space-grown glioblastoma organoids could help advance brain cancer treatments

Glioblastoma (GBM) is the most common malignant primary brain tumor in adults and is one of the most aggressive and deadly forms of cancer. It is difficult for surgeons to fully remove GBM because it often has microscopic "tentacles" that extend from the tumor into healthy brain tissue. GBM is also hard to treat because it creates an immunosuppressive microenvironment that helps the cancer evade immune attack and resist therapy.

Space-Grown Glioblastoma Organoids Could Help Advance Brain Cancer Treatments: Results show that space-grown organoids more closely resemble human glioblastoma tumors than those grown on Earth

Multi-Omics and Spatial Analysis of Microgravity-Grown Glioblastoma Organoids Reveal Superior Modeling of Advanced Disease after Long-Term Spaceflight

To overcome limitations of Earth-based models and leverage the unique advantages of space, the authors utilized a panel of glioblastoma-myeloid organoids cultured for 40 days aboard the International Space Station. [Proceedings of the National Academy of Sciences of the United States of America] Full Article