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Microsoft develops AI tool that can diagnose 'sequentially' like a doctor

The system used multiple AI agents to revise diagnoses, order tests and cut estimated work-up costs while outperforming generalist physicians.

  • On Thursday, Microsoft researchers published a study in Science showing their Diagnostic Orchestrator outperformed generalist physicians in diagnosing complex medical cases using a simulated panel of clinical experts.
  • Unlike existing models that analyze all data simultaneously, the Diagnostic Orchestrator functions sequentially, asking questions and ordering tests step-by-step as doctors do, continuously updating hypotheses based on patient information.
  • In complex medical tests, the system achieved 83.2% diagnostic accuracy versus 36.1% for generalist physicians with references; it scored 80% on emergency department cases compared to 47% for human doctors.
  • Researchers will next test the tool's clinical reasoning at Beth Israel Deaconess Medical Center in Boston, with Dr. Dominic King, Microsoft AI Health's leader, aiming to remove 'the drudgery' from medicine.
  • Microsoft CEO Mustafa Suleyman views this work as advancing toward 'medical superintelligence,' predicting healthcare models will improve significantly within 24 to 36 months while human clinicians remain central to patient care.
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Right

Microsoft presented an artificial intelligence system that investigates medical cases in stages: asks for patient information, selects analyses and reviews its assumptions based on results. Named Microsoft AI Diagnostic Orchestrator (MAI-DxO), it correctly identified the diagnosis in about 83% of the complex cases included in an evaluation, according to the results reported by the company.

Left

Microsoft researchers have developed an artificial intelligence tool to diagnose complex medical cases through a series of steps, including collecting information on the patient, identifying the necessary tests and analysing their results, to propose appropriate diagnosis.

·Syrian Arab Republic (the)
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Lean Left

Microsoft's new AI tool mimics the medical approach and makes diagnoses for complex medical cases twice as accurately and cheaply.

·Zagreb, Croatia
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WTVB broke the news on Thursday, October 22, 2026.
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