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Microsoft develops AI tool that can diagnose 'sequentially' like a doctor

The system used multiple AI agents to revise diagnoses, order tests and cut estimated work-up costs while outperforming generalist physicians.

  • On Thursday, Microsoft researchers published a study in Science showing their Diagnostic Orchestrator outperformed generalist physicians in diagnosing complex medical cases using a simulated panel of clinical experts.
  • Unlike existing models that analyze all data simultaneously, the Diagnostic Orchestrator functions sequentially, asking questions and ordering tests step-by-step as doctors do, continuously updating hypotheses based on patient information.
  • In complex medical tests, the system achieved 83.2% diagnostic accuracy versus 36.1% for generalist physicians with references; it scored 80% on emergency department cases compared to 47% for human doctors.
  • Researchers will next test the tool's clinical reasoning at Beth Israel Deaconess Medical Center in Boston, with Dr. Dominic King, Microsoft AI Health's leader, aiming to remove 'the drudgery' from medicine.
  • Microsoft CEO Mustafa Suleyman views this work as advancing toward 'medical superintelligence,' predicting healthcare models will improve significantly within 24 to 36 months while human clinicians remain central to patient care.
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86 Articles

Lean Left

A new system developed by Microsoft simulates the physician's approach by interviewing patients and then proposing complementary examinations. It surpasses the diagnostic accuracy of experienced clinicians, while reducing costs.

·Paris, France
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Lean Left

Microsoft published in Science magazine the study of an AI that hit more than double the diagnoses of general practitioners in difficult cases. The secret is in the method: instead of receiving the case ready, the system investigates the patient step by step,

·São Paulo, Brazil
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Center

Microsoft AI surpasses general practitioners in the diagnosis of complex cases, reaching up to 87% accuracy.

·Madrid, Spain
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Lean Right

An artificial intelligence tool (AI) called DxO, developed by Microsoft, managed to overcome general practitioners in the diagnosis of complex medical cases, according to a study recently published in the scientific journal Science. DxO stands for Diagnosis Orchestrator and simulates a panel of clinical experts who collaborate to arrive at a diagnosis. Practice exercises before surgery improves results and reduces recovery time, says new researc…

·Rio de Janeiro, Brazil
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WTVB broke the news on Thursday, October 22, 2026.
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