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Metformin’s Mysterious Metal Effect Could Explain Its Big Health Benefits

Study of 200 diabetes patients shows metformin lowers copper and iron but raises zinc levels, possibly linking these changes to its glucose-lowering effects, researchers say.

Summary by Science Daily
Metformin, the world’s most widely used diabetes drug, has long been recognized for its surprising range of benefits beyond lowering blood sugar, from reducing inflammation to lowering cancer risk. Yet its exact mechanism has remained unclear for decades. Now, researchers at Kobe University have uncovered the first clinical evidence that the drug alters levels of key metals in the blood.

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Metformin, a drug widely used to treat diabetes, changes the levels of metals in the blood in humans, which is an important step in understanding the multiple actions of this medicine and designing better ones in the future, according to a study by the University of Kobe, Japan.

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Medical Xpress broke the news in on Sunday, August 31, 2025.
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