US EditionNovel mRNA Nanoparticle Exposes Hidden HIV in White Blood Cells
- Researchers at Melbourne's Peter Doherty Institute discovered a method to expose HIV hidden in white blood cells as reported in May 2025.
- This breakthrough addresses the main challenge that HIV hides inside resting CD4+ T cells, making it undetectable by the immune system and treatments.
- The team developed a novel lipid nanoparticle called LNP X that successfully delivers mRNA into these cells, a feat previously thought impossible.
- One dose of Tat-LNP X increased HIV RNA by 112-fold, with researchers describing this as a 'night and day difference' and reacting with gasps of 'wow.'
- Though the virus was exposed and not eliminated, this advance could lead to combining reactivation with cell-killing therapies, marking progress toward an HIV cure.
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It exploits the technology of the mRNA, but it will serve trials and years before it reaches a possible cure
·Italy
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