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Novel mRNA Nanoparticle Exposes Hidden HIV in White Blood Cells

Researchers at Melbourne's Peter Doherty Institute discovered a method to expose HIV hidden in white blood cells as reported in May 2025.
This breakthrough addresses the main challenge that HIV hides inside resting CD4+ T cells, making it undetectable by the immune system and treatments.
The team developed a novel lipid nanoparticle called LNP X that successfully delivers mRNA into these cells, a feat previously thought impossible.
One dose of Tat-LNP X increased HIV RNA by 112-fold, with researchers describing this as a 'night and day difference' and reacting with gasps of 'wow.'
Though the virus was exposed and not eliminated, this advance could lead to combining reactivation with cell-killing therapies, marking progress toward an HIV cure.

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51 Articles

Covid vaccine tech could one day lead to a cure for HIV

The technology that powered Covid vaccines may also lead scientists to a cure for HIV. Using mRNA, Australian researchers said they were able to trick the virus to come out of hiding, a crucial step in ridding the body of…

1 year ago·Buffalo, United States

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Digi 24

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Australian Researchers Are “Injecting” the Effects of a New Anti-HIV Treatment. Discovery that Could Lead to the Eradication of the Virus.

A link to HIV could soon become a reality of current times. Researchers have found a new way to force the virus no longer to hide in human cells, is shown in a report The Guardian. It is based on ARNm technology, which becomes known worldwide during the Covid-19 pandemic, being used in vaccines produced by Moderna and Pfizer/BioNTech.

1 year ago·Romania

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Radio-Canada

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Is HIV Finally Flushed Out?

Australian scientists claim to have found a new way to attack the HIV reservoir to force it "out of its hiding place."

1 year ago·Montreal, Canada

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The Straits Times

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Used in Covid-19 vaccines, mRNA may help rid the body of HIV

A new study shows how the technology deployed in Covid-19 vaccines helped scientists coax the virus out of hiding. Read more at straitstimes.com.

1 year ago·Singapore

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QNews

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Aussie researchers make breakthrough in search for HIV cure

Jordan Hirst Australian researchers have discovered a new way to force HIV out of hiding within cells, in what they describe as […] The post Aussie researchers make breakthrough in search for HIV cure appeared first on QNews.

1 year ago

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