Lung Tumors Rewire Immune Cells in the Bone Marrow Before They Reach Cancer Sites

Lung tumors rewire immune cells in the bone marrow before they reach cancer sites

Lung tumors don't just evade the immune system. They reshape it at its source. Researchers from the Icahn School of Medicine at Mount Sinai and collaborators report in the September 10 online issue of Nature that tumors rewire immune cells in the bone marrow before they even reach the cancer, suggesting a new target to enhance the durability of current immunotherapy

Lung Cancer Remodels Bone Marrow Immune Cells, Undermining the Body’s

New research from the Icahn School of Medicine at Mount Sinai, published on September 10, 2025, in the prestigious journal Nature, challenges the prevailing understanding of how lung tumors evade the immune system. Until now, it was widely believed that immune suppression in the tumor microenvironment occurred after immune cells had migrated to the tumor […]

Lung Cancer Reprograms Bone Marrow Immune Cells to Promote Tumor Growth

Lung tumors can undermine the immune system long before immune cells reach the tumor, according to new research from investigators at the Icahn School of Medicine at Mount Sinai. Their study, published online in Nature, shows that cues from the lung cancer tumors provide a “first hit” on myeloid progenitors (precursors of macrophages) in the bone marrow, which dampens interferon response and promotes immunosuppression. Once they reach the tumor,…