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Ligand Geometry Steers How Platinum Anticancer Candidates Grip DNA
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1 Articles
Ligand Geometry Steers How Platinum Anticancer Candidates Grip DNA
A new study shows that changing how diphosphine ligands coordinate to cyclometalated platinum(II) complexes switches their DNA-binding mode from attempted intercalation to groove binding and reshapes their cytotoxicity against breast and lung cancer cells.
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