Lab-grown pituitary tumors identify potential new Cushing’s therapy

Lab-grown pituitary tumors identify potential new Cushing’s therapy

Researchers have identified ceritinib, a cancer medication, as a promising treatment candidate for Cushing’s disease after successfully using miniature, lab-grown pituitary tumors, known as organoids, to test its effectiveness. Ceritinib, marketed as Zykadia to treat certain lung cancers, effectively inhibited tumor growth and reduced the tumor-driven excess of adrenocorticotropic hormone (ACTH) in patient-derived organoids, with its efficacy fu…