Kupffer cell reprogramming in embryos explains metabolic disorders in offspring

Kupffer cell reprogramming in embryos explains metabolic disorders in offspring

Children born to obese mothers are at higher risk of developing metabolic disorders, even if they follow a healthy diet themselves.

Maternal Obesity Programs Kupffer Cells, Causes Fatty Liver

In a groundbreaking study published in Nature, researchers have unraveled a profound link between maternal obesity and the early programming of liver disease in offspring, pinpointing a crucial molecular mechanism centered on Kupffer cells (KCs). Kupffer cells, the liver’s resident macrophages, play vital roles in maintaining hepatic homeostasis. This new research elucidates how maternal obesity disrupts their prenatal development through a hypo…