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Joe Manganiello Spent 7 Years Anticipating His Death During Debilitating Autoimmune Disease Battle

The actor says the illness nearly killed him and left him with an ostomy bag after emergency surgery and repeated colonoscopies.

  • Actor Joe Manganiello reveals in his new memoir, 'Bloodlines,' that he battled a mysterious, undiagnosable autoimmune illness for seven years. Ahead of the October 13 release, the 49-year-old told People, "I can't believe I'm alive," saying he feels "reborn" after his recovery.
  • Starting shortly after his 2015 marriage to Sofia Vergara, Manganiello experienced debilitating symptoms including severe abdominal pain, rashes, and fatigue that left him unable to walk. The actor lost 60 pounds and underwent emergency surgery in 2016 to remove part of his intestines.
  • Turning to hydrocodone and fentanyl patches despite his 13 years of sobriety, Manganiello struggled to manage chronic pain. He credited adopting a five-pound chihuahua named Bubbles with saving his life during periods of suicidal ideation.
  • In the book, Manganiello alleges his marriage to Vergara became "devoid of any emotionality whatsoever" amid his illness. He also claims Vergara ridiculed his adoption of Bubbles and refused to hug him when he begged for an embrace.
  • Now symptom-free and engaged to actress Caitlin O'Connor, Manganiello disputes Vergara's previous claims that their 2023 divorce stemmed solely from conflicting views on having children. Vergara has not publicly addressed these specific accusations from his memoir.
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Sofia Vergara and Joe Manganiello are back in focus. What for years was one of Hollywood’s most media stories of love threatens to become a new crossover of versions after their controversial separation. The actor will publish his memoirs on October 13 and some of the ... Continue reading "Sofía Vergara throws a dart at his former Joe Manganiello after his accusations: «When you deal with a narcissist, no matter how much you do for them»"

·Madrid, Spain
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Lean Right

Although more than three years have passed since her separation, Sofia Vergara and Joe Manganiello are back on the stage after the statements that the ex-husband of the actress made about her marriage in her next memoir. Magic Mike’s Last Dance interpreter addressed in her book, Bloodlines, the ... Continue reading "Sofía Vergara did not need words to answer the accusations of her ex-husband in a new book"

·Concepción, Chile
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Lean Right

Joe Manganiello recovers in his memoirs unknown episodes of his seven years alongside the Colombian one, including a disease during which he claims to have felt ridiculed. She has answered without directly mentioning her ex

·Madrid, Spain
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Left

During a serious illness, Joe Manganiello felt thwarted – by his own wife Sofia Vergara, as he recounts in his new book “Bloodlines.”

·Stockholm, Sweden
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Detroit Free Press broke the news in Detroit, United States on Wednesday, October 7, 2026.
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