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JCI Targeting the host factor HGS–viral membrane protein interaction in coronavirus infection
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JCI Targeting the host factor HGS–viral membrane protein interaction in coronavirus infection
While current antivirals primarily target viral proteins, host-directed strategies remain underexplored. Here, we performed a genome-wide CRISPR inhibition (CRISPRi) screening to identify the host protein, hepatocyte growth factor-regulated tyrosine kinase substrate (HGS), facilitating the pan-coronavirus infection both in vitro and in vivo. Mechanistically, HGS interacts with the viral membrane (M) protein, facilitating its trafficking to the E…
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