Immune Cells Can Suppress Insulin Secretion Within Minutes: IIT Kanpur Study
The pathway involves GPR18-triggered sphingolipids, and blocking it restored normal insulin release in mouse studies and donated human tissue, researchers said.
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Immune Cells Can Suppress Insulin Secretion Within Minutes: IIT Kanpur Study
The team has also confirmed that the same pathway is present and active in human pancreatic tissue, which makes it a target for drugs meant to protect insulin production in people with obesity and type 2 diabetes.
How IIT-Kanpur Research Could Revolutionise Diabetes Treatment
Researchers at IIT-Kanpur have identified a molecular pathway where immune cells in the pancreas rapidly suppress insulin release, offering a new target for therapies to protect insulin production in individuals with obesity and Type-2 diabetes. The study found that macrophages use sphingolipids to switch off beta cell insulin secretion within minutes, a process triggered by the GPR18 receptor.
IIT Kanpur study finds new link between immune cells, insulin production and diabetes
IIT Kanpur researchers identified a rapid signalling exchange through which macrophages suppress insulin secretion by beta cells. The pathway offers potential targets for protecting insulin production in obesity and type 2 diabetes.
IIT Kanpur discover how immune cells silence insulin, a new clue in the fight against diabetes
In a breakthrough that changes our understanding of how diabetes develops, researchers at the Indian Institute of Technology Kanpur (IIT Kanpur) have found that immune cells inside the pancreas can switch off insulin release within minutes and have identified the molecular switch that allows them to do it. The study published in the Journal of […]
Scientists at IIT Kanpur have made a significant discovery toward understanding how diabetes develops. The research revealed that certain immune cells in the pancreas can, within minutes, not only inhibit insulin production but also its secretion, leading to diabetes. They also identified the specific biological mechanism by which these cells influence the activity of insulin-producing cells. This discovery raises hopes for the development of ne…
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